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Increased training prevents the impairing effect of intra-amygdala infusion of the non-NMDA receptor antagonist CNQX on inhibitory avoidance expression BJMBR
Roesler,R.; Quevedo,J.; Rodrigues,C.; Madruga,M.; Vianna,M.R.M.; Ferreira,M.B.C..
Intra-amygdala infusion of the non-N-methyl-D-aspartate (NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) prior to testing impairs inhibitory avoidance retention test performance. Increased training attenuates the impairing effects of amygdala lesions and intra-amygdala infusions of CNQX. The objective of the present study was to determine the effects of additional training on the impairing effects of intra-amygdala CNQX on expression of the inhibitory avoidance task. Adult female Wistar rats bilaterally implanted with cannulae into the border between the central and the basolateral nuclei of the amygdala were submitted to a single session or to three training sessions (0.2 mA, 24-h interval between sessions) in a step-down inhibitory...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Amygdala; Non-NMDA receptor; Long-term potentiation; Inhibitory avoidance; Memory; Fear.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300016
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Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats BJMBR
Silveira,P.P.; Xavier,M.H.; Souza,F.H.; Manoli,L.P.; Rosat,R.M.; Ferreira,M.B.C.; Dalmaz,C..
Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upon the ingestion of sweet food. Male adult Wistar rats were divided into two groups: controls and exposed to restraint 1 h/day, 5 days/week for 40 days. Both groups were subdivided into two other groups treated or not with midazolam (0.06 mg/ml in their drinking water during the 40-day treatment). The animals were placed in a lighted area in the presence of 10 pellets...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Feeding behavior; Chronic stress; Benzodiazepines; Midazolam; Sweet taste; Rats.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100013
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Involvement of hippocampal NMDA receptors in retention of shuttle avoidance conditioning in rats BJMBR
Roesler,R.; Kuyven,C.R.; Kruel,A.V.S.; Quevedo,J.; Ferreira,M.B.C..
The purpose of this research was to evaluate the role of hippocampal N-methyl-D-aspartate (NMDA) receptors in acquisition and consolidation of memory during shuttle avoidance conditioning in rats. Adult male Wistar rats were surgically implanted with cannulae aimed at the CA1 area of the dorsal hippocampus. After recovery from surgery, animals were trained and tested in a shuttle avoidance apparatus (30 trials, 0.5-mA footshock, 24-h training-test interval). Immediately before or immediately after training, animals received a bilateral intrahippocampal 0.5-µl infusion containing 5.0 µg of the NMDA competitive receptor antagonist aminophosphonopentanoic acid (AP5) or vehicle (phosphate-buffered saline, pH 7.4). Infusion duration was 2 min per side....
Tipo: Info:eu-repo/semantics/other Palavras-chave: NMDA receptor; Hippocampus; Memory; Conditioning; Fear.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200014
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